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The Effect of L-Carnitine on Wound Healing in Patients With Diabetic Foot Ulcer.

RecruitingPhase 2Ages 30 Years - 75 YearsAllAin Shams University
NCT07768228 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Primary outcome: To evaluate the efficacy of L-Carnitine supplementation on length and depth ulcer size Secondary outcome: To investigate the effect of L-Carnitine supplements on: 1. Vascular endothelial growth factor (VEGF) 2. Inflammatory markers TNF-a (Tumor necrosis factor alpha). 3. Hemoglobin A1C (HbA1c) And Lipid profile (cholesterol, triglycerides, high-density Lipoprotein (HDL) and low-density lipoprotein (LDL)). 4. To assess the type and likelihood of any adverse drug reaction that can be related to L-Carnitine supplementation. 5. QOL (DIABETES 39)

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult Male or Female patients with diabetic neuropathy mean age (30-75) years old. * Having Diabetic neuropathy and Diabetic foot ulcer grade 1-2 (mild- moderate) according to Wagner classification. * Uncontrolled diabetic patients (HbA1c). \< 9 duration of diabetic (5 - 10) years. * All patient treated with stable dose of anti-diabetic medication priors and during the period of the study. Exclusion Criteria: * Patients with other causes of ulcers. * Patient taking any antioxidant supplements including vitamin E, ascorbic acid, omega 3 fatty acid, Coenzyme Q10 within three months prior to enrollment in the study. * Patient with autoimmune disease. * Patient with liver disease or kidney disease. * Patient taking medications for cancer. * Patient with thyroid disease.
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What it tests

  • L- carnitine
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Where

2 sites
Faculty of Pharmacy, Ain Shams University
Cairo, Egypt
Faculty of Pharmacy, Ain Shams University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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