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Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease

Recruitingn/aAges 10 Years - 25 YearsAllKing's College London
NCT07768865 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Age related stiffening and hardening of the arteries is often a slow process, but some conditions such as chronic kidney disease (CKD), seem to increase the rate at which the arteries stiffen even during childhood. High blood pressure (BP) is well known to lead to arterial stiffening and is often seen in children and young people (CYP) with CKD. A greater risk of arterial stiffening has been reported in children CYP with CKD compared to healthy CYP and this is thought to be related to the development of high BP, heart problems, and the worsening of kidney damage. The cause is unknown and is unlikely due to age related changes in the arterial wall seen in older adults. Potential mechanisms contributing to arterial stiffening in CYP with CKD include i) abnormalities in the interaction between the heart and the aorta (the large artery pumping blood away from the heart to the rest of the bo

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion criteria: For CKD participants: * Aged 10-25 years at study entry. * Diagnosis of CKD confirmed on at least two GFR assessments 3-months apartอพ eGFR will be estimated using routine bedside formulae (modified Schwartz). Participants may include those on dialysis or those with a functioning kidney transplant. * Able to tolerate study investigations including 24-hour ABPM, echocardiogram, vascular assessments and MRI. For controls: * Aged 10-25 years at study entry * Having completed study measurements as part of other research being completed by the research group and having consented to their anonymised data being used in future research within the same research theme. Exclusion criteria (for all participants): * Heart abnormalities or pre-existing cardiac disease including congenital heart disease, previous cardiac surgery or heart failure. * Cardiac dysrhythmia. * Inability to tolerate the required study investigations (out of office BP monitoring, applanation tonometry, cardiac MRI).
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What it tests

  • Not listed
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Where

1 site
Evelina London Children's Hospital and Guys and St Thomas' NHS Foundation Trust
London, United Kingdom
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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