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Multimodal Biomarkers in Coronary Artery Disease Pathogenesis: The Oxford Acute Myocardial Infarction Study (OXAMI Study)

Recruitingn/aAges 18 Years - 90 YearsAllUniversity of Oxford
NCT07772570 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Coronary artery disease is one of the most common causes of illness and death. It develops when fatty deposits, known as plaques, build up in the arteries that supply blood to the heart. These plaques can gradually narrow the arteries and reduce blood flow, causing symptoms such as chest pain (angina). Sometimes a plaque can suddenly break open, causing a blood clot to form and block the artery. This can lead to a heart attack and permanent damage to the heart muscle. Although much has been learned about coronary artery disease, important questions remain about why some plaques suddenly become unstable, how this affects blood flow through the smallest blood vessels of the heart, and why some patients develop more heart muscle damage than others. The Oxford Acute Myocardial Infarction (OxAMI) research programme aims to improve our understanding of these processes. The investigators will

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📋 Eligibility rules (as published)
Inclusion Criteria: * Evidence of myocardial injury (e.g. elevation of troponin or other cardiac biomarkers, ECG changes, wall motion abnormalities on cardiac imaging) AND/OR referred for coronary angiography with view to proceed to PCI as indicated in either non-emergency or emergency settings. Exclusion Criteria: * Patients in whom safety or clinical concerns preclude participation. * Anaemia (Hb \<9). * Pregnant or breast feeding females. Additional exclusion criteria for patients undergoing MRI * claustrophobia which limits / prevents participants from remaining in MRI scanner. * patients who cannot lie flat on the scan table. * patients with metallic implants, pacemakers, implantable defibrillators etc, unless known to be MRI compatible. * patients with known allergy to medium of contrast (gadolinium) Additional exclusion criteria for patients undergoing coronary CT angiography * patients with a known allergy to iodinated contrast media * eGFR\< 30 ml/min (stage 3-5 renal disease)
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What it tests

  • blood sampling
  • Intracoronary Imaging
  • Cardiovascular Magnetic Resonance Imaging
  • Cardiac Computerised Tomography
  • Invasive Coronary Physiology
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Where

1 site
Oxford Heart Centre, John Radcliffe Hospital
Oxford, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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