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Uterine Lavage to Detect Ovarian Cancer Risk

RecruitingNAAges 18 Years - anyFemaleUniversity of Washington
NCT07772869 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This clinical trial develops a non-surgical approach using uterine lavage samples to screen for progression to ovarian cancer in high-risk patients carrying BRCA mutations. Women with inherited mutations in the BRCA1 and BRCA2 genes (BRCA carriers) have a much higher lifetime risk of developing ovarian cancer. Currently there are no effective ovarian cancer screening or early detection tests for BRCA carriers. Uterine lavage is a procedure that uses saline to rinse and collect cells from the fallopian tube. Molecular analysis of these samples may help proactively detect genetic alterations that are indicative of progression to ovarian cancer in women with BRCA mutations.

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📋 Eligibility rules (as published)
Inclusion Criteria: * \> 18 years of age * Have a pathogenic BRCA1 or BRCA2 germline variant * Planned risk-reduction surgery * Presence of uterus and at least one fallopian tube Exclusion Criteria: * Prior tubal ligation * Prior history of known ovarian or endometrial cancer
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What it tests

  • Uterine Lavage
  • Archive Sample
  • Survey Administration
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Where

1 site
Fred Hutch/University of Washington Cancer Consortium
Seattle, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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