STN-tTIS With Different Intervention Intervals Versus Standard Medical Treatment for Parkinson's Disease

Inclusion Criteria: * 1.Aged 50-85 years, male or female. * 2.Diagnosed with idiopathic Parkinson disease (PD) in accordance with the Chinese Guidelines for the Diagnosis and Treatment of Parkinson's Disease (4th Edition), with a confirmed diagnosis for at least 6 months and a stable condition, defined as no significant deterioration or major medication adjustment within the past month. * 3.Receiving stable doses of antiparkinsonian medication (e.g., levodopa or dopamine agonists) and willing to maintain the medication regimen during the study. * 4.Hoehn and Yahr stage 1-3 in the medication ON state. * 5.Baseline MDS-UPDRS Part III total score ≥20 in the medication ON state. * 6.No history of non-invasive neuromodulation therapy, or discontinuation of such therapy for at least 3 months before enrollment if previously received. * 7.Normal cognitive function (MoCA score ≥24) and able to cooperate with tTIS intervention, clinical scale assessments, and basic smartphone- and smartwatch-assisted home-based motor self-assessments. * 8.Able and willing to provide written informed consent and complete all required study procedures and follow-up assessments. Exclusion Criteria: * 1.Other neurological disorders that may affect motor or cognitive function. * 2.Contraindications to magnetic resonance imaging (MRI), such as claustrophobia. * 3.History of taking antipsychotics, antidepressants, or other medications affecting dopamine levels. * 4.Psychiatric disorders (e.g., depression or schizophrenia), substance abuse, or alcohol dependence. * 5.Implanted medical devices (e.g., pacemaker or defibrillator), metal implants in the cranium or spine, a personal or family history of epilepsy, or severe skull defects. * 6.Previous deep brain stimulation (DBS) or other intracranial implantation surgery, or participation in another Parkinson disease clinical trial within the past 3 months.