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Study of Correlation Between the Level of Intradiscal Periostin Expression and Pfirrmann Grading

Recruitingn/aAges 20 Years - 80 YearsAllKeimyung University Dongsan Medical Center
NCT07776366 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Intervertebral disc degeneration (IVDD) is a well-recognized musculoskeletal condition that imposes a substantial socioeconomic burden and is an important cause of low back pain. IVDD can result from a variety of factors, including aging, obesity, genetic predisposition, degeneration of the multifidus and psoas muscles, osteoporosis, inflammation, and oxidative stress. The intervertebral disc (IVD) within the spine is composed of a gel-like nucleus pulposus (NP) at its center, a surrounding annulus fibrosus (AF), and cartilaginous endplates above and below. The NP and AF produce a water-rich extracellular matrix (ECM), which contributes to normal functioning of the spinal column. Various internal and external stimuli cause dysfunction of the NP and AF, and excessive metabolic activity of the endplates leads to endplate degeneration and calcification, ultimately resulting in disc degener

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📋 Eligibility rules (as published)
Inclusion Criteria: * lumbar disc herniation * lumbar spinal canal stenosis * patients who have MRI Exclusion Criteria: * allergic disease * allergic rhinitis * asthma * atopic dermatitis * chronic sinusitis * history of cancer * fracture within 6 months * severe osteoporosis * knee osteoarthritis * hip osteoarthritis * spinal surgery within 6 months * myocardiac infarction * heart failure * liver cirrhosis
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What it tests

  • posterior lumbar interbody fusion
  • lumbar discectomy
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Where

1 site
Ji Hee
Daegu, South Korea
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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