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The Prediction of Clinical Outcome Using the Serum BDNF Level

Recruitingn/aAges 20 Years - 80 YearsAllKeimyung University Dongsan Medical Center
NCT07776379 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Low back pain (LBP) is one of the most commonly observed conditions in patients over the age of 50 and imposes a substantial socioeconomic burden. Degenerative disc disease is one of the most frequent and important causes of this pain. Progressive disc degeneration is characterized by a decline in disc cell number and degradation of the extracellular matrix. Loss of nucleus pulposus (NP) volume and hydration, together with fissure formation within the annulus fibrosus (AF), develop gradually with aging and ultimately lead to functional impairment. Disc degeneration can result from multiple factors, including aging, obesity, genetic predisposition, degeneration of the multifidus and psoas muscles, osteoporosis, inflammation, and oxidative stress. The intervertebral disc consists of the gel-like nucleus pulposus (NP) at its center, the surrounding annulus fibrosus (AF), and the cartilagino

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📋 Eligibility rules (as published)
Inclusion Criteria: * Chronic low back pain patients with or without leg pain due to disc degeneration or spinal stenosis * Patients who have MRI Exclusion Criteria: * Secondary low back pain (spine fracture, infection, tumor) * recent history of spine surgery * systemic inflammatory disease (rheumatoid arthritis, SLE, ankylosing spondylitis) * peripheral neuropathy or central nervous system injury * fibromyalgia * drugs which can affect the serum BDNF level (anti depressant, anti parkinsonian drug, acetylcholinesterase inhibitor, anti psychotics)
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What it tests

  • Erector Spinae Plane Block
  • Blood sampling for ELISA
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Where

1 site
Ji Hee
Daegu, South Korea
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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