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Deep Endometriosis Affecting the Urogenital Tract: Long-term Outcomes and Impact on Renal Function

Recruitingn/aAges 18 Years - anyFemaleCharles University, Czech Republic
NCT07776574 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Endometriosis is a chronic estrogen-dependent disease characterized by the presence and growth of endometrium-like tissue outside the uterine cavity. This ectopic endometrial tissue induces a chronic local and systemic inflammatory response, resulting in the most common manifestations of the disease: chronic pelvic pain, infertility, and pelvic adhesions. In deep endometriosis (DE), adhesions and infiltrative growth may damage adjacent organs. Overall, endometriosis affects approximately 10% of women of reproductive age. Its prevalence is higher among women with infertility (20-50%) and among patients with chronic pelvic pain (up to 90%). The disease is usually categorized as superficial peritoneal, ovarian, or deep endometriosis (DE). Deep endometriosis is a progressive form of the disease that may affect organs beyond the pelvic cavity, including the urinary tract, alter their anato

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📋 Eligibility rules (as published)
Inclusion Criteria:• age ≥ 18 years; * hydronephrosis caused by DE-related ureteral stenosis; * for Group F: a history of surgical treatment of ureteral endometriosis (ureterolysis, ureteroureterostomy, UCNA) at our center at least 24 months previously; * for Group S: indication for surgical treatment because of hydronephrosis or clinically significant ureteral stenosis; * signed informed consent. Exclusion Criteria:• pregnancy; * malignancy; * congenital uropathy; * other renal diseases; * inability to undergo dynamic renal scintigraphy (e.g., allergy to the radiopharmaceutical or severe comorbidities precluding the examination); * previous urinary tract surgery unrelated to ureteral endometriosis that could substantially confound the assessment of renal function.
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What it tests

  • Not listed
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Where

1 site
General University in Prague
Prague, Czechia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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