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Magnesium Sulphate With Atropine and Pralidoxime vs Standard Therapy Alone in Acute Organophosphate Poisoning

RecruitingNAAges 18 Years - 50 YearsAllMuhammad Aamir Latif
NCT07777835 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Pakistan, being a developing country, is one of the regions with the most cases of organophosphate (OP) poisoning/toxicity. MgSO4 is one of the most promising adjunctive treatments that needs to be tested. This study is being carried out with the objective of comparing the 15-day all-cause mortality rate and the total cumulative atropine requirement during hospitalization between patients receiving adjunctive magnesium sulphate with standard therapy and those receiving standard therapy alone.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Both genders * Adult patients aged between 18 and 50 years * Confirmed clinical diagnosis of organophosphate poisoning containing insecticide, through the oral route * Adult patients, or their legally authorized representative, who will provide informed consent to participate in the study Exclusion Criteria: * Patients with known allergy to MgSO4 * Patients with documented pre-existing renal impairment (Serum creatinine more than 1.5mg/dl) * Patients with documented pre-existing cardiac impairments (e.g., heart block) * Pregnant or lactating women * Confirmed intake of any other drug or poison * Patients who will be declared dead on arrival or those who expired within 2 hours of presentation
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What it tests

  • Atropine plus pralidoxime
  • Atropine and pralidoxime with adjunctive MgSO4
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Where

1 site
Nishtar Hospital/Medical University
Multan, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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