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Comparison of High- Versus Low-Dose Aspirin for Pregnancy Outcomes in Women at High Risk of Preeclampsia

RecruitingPhase 4Ages 18 Years - 45 YearsFemaleMedicare Hospital (Pvt) Limited
NCT07779057 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this randomized clinical trial is to compare the effects of two doses of aspirin, 75 mg and 150 mg, in pregnant women who are at high risk of developing preeclampsia. The main question the study aims to answer is: 1. Does taking 150 mg of aspirin reduce the occurrence of preeclampsia more effectively than taking 75 mg of aspirin in pregnant women at high risk of preeclampsia? 2. Are there differences in stillbirth and newborn birth weight between the two aspirin doses? The study will include 224 pregnant women aged 18-45 years who are between 11 and 14 weeks of pregnancy and are identified as being at high risk for preeclampsia. Participants will be randomly assigned to one of two groups. * Participants in the low-dose group will take 75 mg of aspirin once daily at bedtime. * Participants in the high-dose group will take 150 mg of aspirin once daily at bedtime. Participa

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📋 Eligibility rules (as published)
Inclusion Criteria: * Gestational age 11-14 weeks * High risk of preeclampsia Exclusion Criteria: * Active gastritis * Abnormal coagulation profile (INR \> 1.5) * Renal disease * Platelet count \< 150,000/mm\^3 * Fetal malformations * Vaginal bleeding
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What it tests

  • Aspirin
  • Aspirin
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Where

1 site
Medicare Hospital (Pvt) Ltd.
Multan, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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