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Volume-Stable Collagen Matrix vs. Connective Tissue Graft for Peri-Implant Soft Tissue Defects

RecruitingNAAges 18 Years - 65 YearsAllAnkara University
NCT07782125 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Peri-implant soft-tissue defects will be treated with either a volume-stable collagen matrix (VCMX; test group) or an autogenous connective tissue graft (CTG; control group) following implant placement in patients with a single missing tooth. After a mid-crestal incision and full-thickness flap elevation, the graft material will be positioned over the crest beneath the buccal flap and stabilized, followed by tension-free primary closure. Peri-implant soft-tissue thickness, echo intensity, and vascularization will be assessed non-invasively using high-resolution intraoral ultrasonography and Power Doppler imaging. Clinical periodontal parameters and patient-reported outcomes, including pain perception (visual analog scale), swelling, fatigue, analgesic consumption, and wound healing, will be recorded. These outcomes will be evaluated at baseline and on the 1st week, 1st, 3rd, and 6th mont

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \>18 years * Periodontal health confirmed according to the 2017 World Workshop criteria (BOP \<10%, PD ≤3 mm, absence of gingival inflammation, and good oral hygiene) (Tonetti et al., 2018) * Requirement of implant placement and soft-tissue augmentation for a single missing tooth in the anterior region * Bleeding on probing \<30% at the adjacent teeth (Thoma et al., 2016) * Compliance with the study protocol and follow-up visits Exclusion Criteria: * Siebert Class II or Class III defects * History of surgery at the treated site * Untreated periodontitis or peri-implantitis * Current smoking or smoking within the previous five years * Systemic conditions (that may impair healing) * Pregnancy or lactation * Allergy to the materials/drugs used * Drug use affecting mucosal healing * History of antibiotic therapy within the previous six months
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What it tests

  • Connective tissue graft
  • Volume-stable collagen matrix
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Where

1 site
Faculty of Dentistry, Ankara University
Ankara, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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