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Critical Hyperacute Assessment Research On Neurobiomarker Kinetics in Acute Brain Injury

Recruitingn/aAges 18 Years - anyAllUniversity of Pecs
NCT07782216 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Traumatic brain injury (TBI) and other conditions that reduce blood flow to the brain - such as cardiac arrest (CA) - are life-threatening medical emergencies. When brain cells are damaged, they release specific proteins into the bloodstream. These proteins, called neurobiomarkers, can be measured in blood samples and may help doctors assess the severity of brain injury, guide treatment, and predict patient outcomes. A major gap in current knowledge is how these neurobiomarkers behave during the very first minutes and hours after injury - the so-called "hyperacute" phase - especially when patients are still being treated by paramedics or have just arrived at the emergency department (ED). It is not yet clear whether biomarker levels rise immediately at the moment of injury or gradually over time, and how quickly they can be reliably detected. The CHARON study investigates the time-depe

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📋 Eligibility rules (as published)
Inclusion Criteria * Age 18 years or older (all arms) * Polytraumatized patients categorized as T1 triage by the first responder based on injury mechanism and/or sustained injuries, with intubation indicated by the first responder (Arm 1) * Cardiac arrest treated in the prehospital setting (Arm 2) * Severe traumatic brain injury enrolled at hospital admission (Arm 3) Exclusion Criteria (all arms) * Age under 18 years * Pre-existing neurological or psychiatric conditions * Hypothermia or hyperthermia at the time of enrollment * Pregnancy
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What it tests

  • Not listed
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Where

4 sites
University of Pécs Clinical Center, Department of Emergency Medicine
Pécs, Hungary
Petz Aladár University Teaching Hospital, Emergency Department
Győr, Hungary
Hungarian National Ambulance Service
Budapest, Hungary
North Pest Central Hospital - Military Hospital, Emergency Centre
Budapest, Hungary
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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