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Expression of TSLP Isoforms in Asthma

Recruitingn/aAges 18 Years - anyAllMedical University of Warsaw
NCT07786870 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Asthma is a heterogeneous disease characterized by chronic airway inflammation, leading to variable airflow obstruction, bronchial hyperresponsiveness, excessive mucus secretion, and, consequently, structural airway remodeling. Asthma is defined by the presence of symptoms such as wheezing, dyspnea, chest tightness, and cough, with variable intensity and frequency. Thymic stromal lymphopoietin (TSLP) is a cytokine produced primarily by epithelial cells in the lungs. Two distinct isoforms of TSLP have been identified: a long form (lfTSLP) and a short form (sfTSLP). The long isoform is induced during inflammatory conditions and promotes a T2-dependent immune response. In contrast, the short isoform is believed to exert homeostatic and anti-inflammatory functions and exhibits antimicrobial properties. Studies have demonstrated an association between elevated serum and airway TSLP levels a

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📋 Eligibility rules (as published)
1. Inclusion criteria * age \> 18 years, without the upper age limit, * asthma (diagnosis in accordance with the GINA 2023 guidelines), 2. Exclusion criteria * other respiratory diseases (e.g., chronic obstructive pulmonary disease \[COPD\]); * active cigarette smoking or a smoking history of \>10 pack-years; * active malignancy; * active pulmonary tuberculosis or active respiratory tract infection; * use of antibiotics within 4 weeks prior to study enrollment; * current long-term home oxygen therapy (\>15 hours per day); * current treatment with monoclonal antibody therapies (e.g., omalizumab, mepolizumab, reslizumab, dupilumab, tezepelumab, or other biologics); * pregnancy.
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What it tests

  • No Intervention: Observational Cohort
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Where

1 site
Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland,
Warsaw, Poland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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