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QL Block Versus EO Plane Block for Analgesia After Open Nephrectomy

RecruitingNAAges 18 Years - 65 YearsAllCairo University
NCT07787221 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective randomized clinical trial aims to compare two ultrasound-guided regional anesthesia techniques, the transmuscular quadratus lumborum (QL) block and the external oblique (EO) plane block, for pain relief after open nephrectomy. Open nephrectomy is a major surgical procedure that can cause significant postoperative pain and may require opioid medications for adequate pain control. Adult patients undergoing open nephrectomy at the National Cancer Institute, Cairo University, who meet the study eligibility criteria will be randomly assigned to receive either a QL block or an EO plane block before surgery. Both techniques will be performed under ultrasound guidance using bupivacaine in addition to standardized general anesthesia and multimodal postoperative analgesia. The main purpose of the study is to determine whether the QL block provides better postoperative analgesia

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📋 Eligibility rules (as published)
\*\*Inclusion Criteria:\*\* * Adult patients aged 18 to 65 years. * Patients undergoing open nephrectomy at the National Cancer Institute, Cairo University. * American Society of Anesthesiologists (ASA) physical status II-III. * Body mass index (BMI) greater than 20 kg/m² and less than 35 kg/m². \*\*Exclusion Criteria:\*\* * Patient refusal to participate. * ASA physical status IV. * Age less than 18 years or greater than 65 years. * BMI less than 20 kg/m² or greater than 35 kg/m². * Known allergy or contraindication to any study medication, including local anesthetics or opioids. * History of psychiatric disorders or chronic pain. * Contraindications to regional anesthesia, including local infection at the injection site, pre-existing neuropathy, or coagulopathy. * Severe organ dysfunction, including cardiac dysfunction (ejection fraction \<40%), respiratory dysfunction (FEV1 \<50% of predicted or requirement for home oxygen therapy), hepatic dysfunction (Child-Pugh class C), or renal dysfunction (estimated glomerular filtration rate \<30 mL/min/1.73 m²).
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What it tests

  • Quadratus Lumborum Block (QLB)
  • External Oblique Plane Block
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Where

2 sites
Cairo University
Cairo, Egypt
Cairo University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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