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Effects of High-Frequency rTMS on Cortical Motor Mapping in Stroke Patients With Severe Upper Limb Impairment (MAP2024SJD)

RecruitingNAAges 18 Years - anyAllAncor Rebassa Cabrera
NCT07787793 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if a single session of high-frequency repetitive transcranial magnetic stimulation (rTMS) can increase cortical motor activity in stroke patients with severe upper limb impairment. The main question it aims to answer is: Does one session of high-frequency rTMS increase the number of motor evoked potential (MEP)-positive points in the cortical motor map of the affected hemisphere compared to sham stimulation? Researchers will compare high-frequency rTMS (10 Hz, 600 pulses) applied over the affected motor cortex to sham stimulation to see if rTMS increases detectable cortical motor responses in patients who have little or no voluntary hand movement after stroke. Participants will: Undergo a cortical motor mapping assessment before the intervention. Receive either one session of real rTMS or sham stimulation, depending on their randomly assig

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📋 Eligibility rules (as published)
Inclusion Criteria: * First-ever stroke confirmed by MRI or CT scan. * Inability to voluntarily activate the hand musculature: manual muscle testing score of 1 or less in finger extension. * Time since stroke onset greater than 6 months. Exclusion Criteria: * History of craniotomy or metallic implants in the skull. * Diagnosis of uncontrolled epilepsy. * Diagnosis of other neurological diseases (dementia, Parkinson's disease, neuropathies, multiple sclerosis, or similar conditions). * Low level of consciousness or significant cognitive impairment that prevents informed consent or study collaboration. * Diagnosis of rheumatic disease or presence of hand deformities. * Pregnancy.
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What it tests

  • High-frequency repetitive transcranial magnetic stimulation
  • Sham transcranial magnetic stimulation
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Where

1 site
Hospital Sant Joan de Déu Palma
Palma, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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