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Effects of Fospropofol Disodium TIVA and IVIH on Surgical Field Quality in Adult ESS

RecruitingNAAges 18 Years - 65 YearsAllTongji Hospital
NCT07788157 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Endoscopic sinus surgery (ESS) is a primary surgical approach for treating chronic rhinosinusitis, nasal polyps, and other conditions that are unresponsive to conservative therapy. A clear surgical field is a critical prerequisite for ensuring precision, efficiency, and the avoidance of injury to vital structures such as the orbit and the skull base. Currently, the anesthetic regimens commonly used for ESS include total intravenous anesthesia (TIVA), inhalational anesthesia (IA), and intravenous-inhalational combined anesthesia (IVIH). However, there remains controversy regarding the comparative effects of these three modalities on surgical field quality. IVIH, as an anesthetic strategy that integrates the advantages of both intravenous and inhalational agents, is widely employed in clinical practice. In the context of ESS, it may reduce the dose of individual agents through combination

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📋 Eligibility rules (as published)
Inclusion Criteria: * age 18-65 years * ASA physical status I-II * BMI 18-35 kg/m² * diagnosed with chronic rhinosinusitis (with or without nasal polyps) and scheduled for elective endoscopic sinus surgery * provided written informed consent Exclusion Criteria: * uncontrolled hypertension or asthma * use of medications that may affect coagulation function (e.g., NSAIDs) within 1 week prior to surgery * pre-existing coagulation abnormalities * history of bleeding disorders * history of drug allergy (to propofol, fospropofol disodium, or sevoflurane) * other comorbidities, such as uncorrected congenital heart disease, neuromuscular disorders, or hepatic/renal dysfunction * recent participation in other clinical studies
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What it tests

  • Fospropofol disodium
  • Propofol
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Where

1 site
Tongji Hospital
Wuhan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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