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A Comprehensive, Multimodal Characterization of Prodromal PD in Subjects With RBD

Recruitingn/aAges 18 Years - anyAllDanish Research Centre for Magnetic Resonance
NCT07790744 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Comprehensive characterization of early-stage Parkinson's disease in patients with REM sleep behavior disorder Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder worldwide, significantly affecting quality of life and causing substantial social and economic burdens. Currently, treatments for Parkinson's disease primarily manage symptoms through medication and lifestyle changes but cannot stop disease progression. By the time Parkinson's disease is diagnosed, substantial nerve-cell loss has already occurred in specific brain areas. Identifying early signs of PD before symptoms fully develop is essential for improving future treatment strategies. This research project aims to deeply understand the earliest stages of Parkinson's disease by studying patients with REM sleep behavior disorder (RBD). RBD is a condition characterized by unusual movements or behaviors dur

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📋 Eligibility rules (as published)
Inclusion Criteria: Both groups - The ability to give informed consent For RBD-group * Verified REM-sleep behaviour disorder via polysonography * No other significant neurological and psychiatric ilness For Healthy controls \- Age matched to RBD-group Exclusion Criteria: * Ferrous objects in or around the body * Pacemaker or other implanted electronic devices * Drug abuse unrelated to medication or alcohol abuse over a period of 6 months prior to the experiment * Other major immunological, cardiac, neurological or neuropsychiatric disorders * Claustrophobia * Incapability of giving informed consent * Unwillingness to be informed about abnormal findings. * Participation in clinical trials involving drug testing over a period of 6 months prior to the experiment. * Disease symptoms leading to excessive movement inside the scanner (e.g., excessive tremor)
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What it tests

  • Not listed
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Where

1 site
Danish Research Centre for Magnetic Resonance
Hvidovre, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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