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Study to Assess Adverse Events and How Effective NOA LIFT is Compared to JUVÉDERM VOLIFT With Lidocaine for the Correction of Nasolabial Folds in Adults

RecruitingPhase 3Ages 18 Years - anyAllAbbVie
NCT07794878 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Nasolabial folds (NLFs) are wrinkles that run from the sides of the nose to the corners of the mouth. The goal of this study is to evaluate how safe and effective NOA LIFT is compared to JUVÉDERM VOLIFT with Lidocaine for correcting moderate to severe nasolabial folds in adults. NOA LIFT and JUVÉDERM VOLIFT with Lidocaine are hyaluronic acid-based dermal fillers being evaluated for the treatment of nasolabial folds. Participants are randomly placed into 1 of 2 treatment groups. There is a 2 in 3 chance that participants will be assigned to the NOA LIFT group and a 1 in 3 chance of being assigned to the VOLIFT group. Around 288 adult participants with moderate to severe nasolabial folds will be enrolled at multiple sites in China. Participants will receive deep dermis injections of either NOA LIFT or JUVÉDERM VOLIFT. The study duration is approximately 12 months after the initial treatm

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📋 Eligibility rules (as published)
Inclusion Criteria: \- Moderate (2) or Severe (3) on the 5-point Nasolabial Fold Severity Scale (NLFSS) for each nasolabial fold (NLF) on evaluator live assessment (both sides must qualify and have the same score) Exclusion Criteria: * Current cutaneous or mucosal inflammatory or infectious processes, abscess, unhealed wound, or cancerous or precancerous lesion in the treatment area(s). * Current enrollment in an investigational drug or device study or participation in such a study within 30 days before enrollment.
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What it tests

  • NOA LIFT
  • JUVÉDERM VOLIFT with Lidocaine
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Where

6 sites
Peking Union Medical College Hospital (West) - Xidan Campus /ID# 267457
Beijing, China
Zhujiang Hospital /ID# 276566
Guangzhou, China
Peking University Shenzhen Hospital /ID# 268255
Shenzhen, China
Nanjing Drum Tower Hospital /ID# 267555
Nanjing, China
Zhongda Hospital Of Southeast University /ID# 276571
Nanjing, China
Xianyang Hospital of Yanan University /ID# 267936
Xianyang, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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