Ipsilateral Versus Bilateral Systematic Biopsy Combined With MRI/Ultrasound Cognitive Fusion Targeted Biopsy for Prostate Cancer Diagnosis

Inclusion Criteria: * Male participants older than 18 years. * Suspected prostate cancer and scheduled to undergo transperineal prostate biopsy. * Prostate MRI showing a unilateral lesion with a highest Prostate Imaging Reporting and Data System (PI-RADS) score of 4 or 5. * Serum prostate-specific antigen (PSA) level of 20 ng/mL or lower. * Able to tolerate and undergo transperineal prostate biopsy. * Willing to participate in the study and able to provide written informed consent. Exclusion Criteria: * Prior prostate biopsy. * Prior prostate-related treatment or procedure that may affect pathological assessment or interpretation of the biopsy results, including but not limited to androgen deprivation therapy for prostate cancer, radiotherapy, focal therapy, or transurethral prostate surgery. * Prostate MRI showing a lesion crossing the prostatic midline such that the lesion side cannot be clearly determined, or an independent contralateral lesion with a PI-RADS score of 3 or higher. * Acute urinary tract infection, severe coagulation disorder, or any other contraindication to transperineal prostate biopsy. * In the investigator's judgment, inability to understand the study, comply with study procedures, or provide written informed consent.