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Feasibility Study of Blood Biomarker Identification in Cervical Cancer

Recruitingn/aAges 18 Years - anyFemaleQueensland Centre for Gynaecological Cancer
NCT07796672 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to explore whether a simple blood test can be used to help detect and monitor cervical cancer. The investigators are studying tiny fragments and particles found in blood, called cell-free DNA (cfDNA) and extracellular vesicles (EVs), to determine whether these can act as early warning signs (biomarkers) of cervical cancer. Cell-free DNA (cfDNA) refers to tiny fragments of genetic material (DNA) that are naturally released from cells into the bloodstream when cells die or renew. Cell-free DNA circulates naturally in the blood. In people with cancer, some of the cfDNA originates from cancer cells; this component is called circulating tumour DNA (ctDNA). Analysis of cfDNA can detect signs of cancer, such as specific genetic changes or pieces of viral DNA, including human papillomavirus (HPV) DNA, without requiring removal of tissue from the cervix. Extracellular vesicles (

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📋 Eligibility rules (as published)
Inclusion Criteria: * Females, over 18 years, with histologically confirmed squamous cell carcinoma or adenocarcinoma of the cervix (stage 1a to 4b) * Undergo intensive primary surgical treatment, radiotherapy (RT) or chemoradiotherapy (CRT). * Signed written informed consent Exclusion Criteria: * Unable to provide informed consent * Serious concomitant systemic disorders incompatible with the study (at the discretion of the investigator) * Prior malignancies \<5 years before inclusion, except for successfully treated keratinocyte skin cancers, or ductal carcinoma in situ.
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What it tests

  • Blood Sample Collection
  • cfDNA and Extracellular Vesicle Biomarker Analysis
  • Patient-Reported Outcome and Quality-of-Life Assessment
  • Tumour Tissue Biomarker Analysis
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Where

1 site
Royal Brisbane and Women's Hospital
Brisbane, Australia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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