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Role of Allopurinol in Prevention of Complications Related to Decompensated Cirrhosis of Liver

RecruitingPhase 4Ages 18 Years - 70 YearsAllBangladesh Medical University
NCT07800598 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cirrhosis, a leading cause of global mortality, progresses to life-threatening complications like ascites, hepatic encephalopathy, and hepatorenal syndrome. Oxidative stress and gut-liver axis dysfunction drive disease progression. Allopurinol, a xanthine oxidase inhibitor, has shown potential in reducing complications in cirrhosis, but robust clinical evidence is lacking. This study will evaluate allopurinol's efficacy in preventing complications in decompensated cirrhosis. This study aims to assess whether allopurinol reduces cirrhosis-related complications (ascites, variceal bleeding, hepatic encephalopathy, SBP, HRS-AKI) and improves MELD/CTP scores in Child-Pugh B/C cirrhosis patients. This study will select 54 patients with decompensated cirrhosis (Child-Pugh B/C). Patients aged 18-70 years, with any etiology of cirrhosis (viral, alcoholic, NAFLD). Patients with acute decompensat

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📋 Eligibility rules (as published)
Inclusion Criteria: * • Adult patients (age : 18-70 years) diagnosed with Decompensated cirrhosis of liver with any etiology of cirrhosis . * CTP score B or C . Exclusion Criteria: * • Patients with known hypersensitivity or allergy to allopurinol. * Patients with active HE or SBP or HRS-AKI or a history of any of these events within the last 4 weeks. * Patients with advanced renal impairment (e.g., creatinine clearance \<30 mL/min). * Pregnant or breastfeeding women. * Patients with severe comorbidities (e.g., uncontrolled cardiovascular disease, cancer, or severe infections). * Patients currently using medications that interact with allopurinol (e.g., azathioprine, mercaptopurine, Cyclophosphamide, Thiazide diuretics ,Warfarin, Theophyllin ).
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What it tests

  • Allopurinol Tablet
  • Placebo
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Where

2 sites
Department of Hepatology at Bangladesh Medical University.
Dhaka, Bangladesh
Department of Hepatology at Bangladesh Medical University.
Dhaka, Bangladesh
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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