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Postoperative Edge (RapidArc) Stereotactic Body Radiotherapy for Spinal Metastases

Recruitingn/aAges 18 Years - 80 YearsAllTianjin Medical University Cancer Institute and H…
NCT07801274 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study observes the effectiveness of high-precision radiation therapy using the Edge system after surgery for patients with spinal metastases. Spinal metastases can press on the spinal cord and cause pain, weakness, or paralysis. This treatment uses higher doses of radiation in fewer sessions (hypofractionated stereotactic body radiotherapy) delivered precisely by the Edge machine to target remaining tumor cells while protecting the spinal cord. The study aims to see if this approach improves local tumor control, improves neurological function, shortens treatment duration, and improves quality of life in these patients. The study is observational, meaning patients receive standard care, and data is collected to evaluate the outcomes.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age 18 to 80 years, any sex. 2. Karnofsky Performance Status (KPS) \>= 60 or ECOG Performance Status \<= 2. 3. Confirmed spinal metastases from solid tumors by pathology or imaging (MRI/CT). 4. Postoperative imaging confirming residual epidural spinal cord compression (MESCC) requiring adjuvant radiotherapy. 5. Number of lesions \<= 5, and maximum diameter of a single lesion \<= 5 cm. 6. Interval between surgery and radiotherapy \<= 4 weeks. 7. Signed informed consent and willingness to participate in the study. Exclusion Criteria: 1. Uncontrolled primary tumor (e.g., extensive metastasis or progressive disease). 2. Concurrent brain metastases or other active malignancies. 3. Pathological fracture or severe spinal instability requiring emergency surgical intervention. 4. Prior cumulative spinal cord radiation dose exceeding the tolerance threshold (e.g., previous spinal cord Dmax \>= 45 Gy). 5. Contraindications to radiotherapy (e.g., severe cardiopulmonary dysfunction, coagulation disorders). 6. Severe postoperative complications (e.g., infection, poor wound healing) requiring delayed radiotherapy. 7. Incomplete or unreliable medical records from external hospitals. 8. Pregnant or lactating women.
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What it tests

  • Stereotactic Body Radiotherapy
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Where

1 site
300060
Tianjin, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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