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Effect of Intravenous Magnesium on Postoperative Systemic Inflammatory Response in Patients Undergoing Colorectal Cancer Surgery

RecruitingNAAges 35 Years - 75 YearsAllAin Shams University
NCT07803601 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to detect the effect of intraoperative intravenous magnesium sulfate on postoperative systemic inflammatory response by serum inflammatory parameters as CRP, WBCS and neutrophil count.

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📋 Eligibility rules (as published)
Inclusion Criteria: * ASA I and ASA II. * Age (35yrs - 75yrs). * Patients undergoing open colorectal cancer surgery. * Sex: Both sexes. Exclusion Criteria: * Renal impairment (Glomerular Filtration Rate \< 60 ml\\min). * Severe cardiac dysfunction (Ejection fraction ≤ 30% or clinical signs and symptoms of reduced left ventricular ejection fraction), preoperative bradycardia (HR \< 50 bpm) and atrioventricular block (first, second and third degree). * Allergy to study drug (MgSO4). * Patient refusal to precipitate in this study. * Autoimmune disorders (eg: rheumatoid arthritis, multiple sclerosis and lupus), congenital and acquired immunodeficiency. * Previous / current immunomodulatory therapy. * Emergency condition (eg: obstruction or perforation in colorectal cancer). * Postoperative complications altering inflammatory response (eg: infection, anastomotic leak). * Duration of operation \> 5 hours. * Cognitive impairment (eg: Dementia) and other psychiatric disorders by history. * Body mass index less than 18 or greater than 30 kg/m².
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What it tests

  • Magnesium sulfate (MgSO4)
  • Normal Saline
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Where

1 site
Ain shams university
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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