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Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)

Recruitingn/aAges 18 Years - anyAllSecond Affiliated Hospital of Soochow University
NCT07805967 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and characteristic imaging evolution patterns. Establish a comprehensive assessment framework for APS, and develop clinical and biological databases to identify biomarkers with early predictive value.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. MSA : Meets the "probable MSA" criteria in the 2022 Chinese expert consensus on MSA diagnosis (MSA-P or MSA-C subtype); disease duration ≤3 years (from onset of first motor symptoms) . 2. DLB : Meets "probable DLB" criteria per the 2017 McKeith diagnostic criteria; MMSE ≥18 (to exclude severe dementia confounding assessment) . 3. PSP : Meets "probable PSP-Richardson syndrome" criteria per the 2017 PSP diagnostic standards; vertical gaze palsy or postural instability with duration ≤2 years . 4. CBD : Meets "probable CBD" criteria per the 2019 Chinese expert consensus on corticobasal degeneration diagnosis and treatment; asymmetric cortical symptoms (apraxia/dystonia/alien limb). Exclusion Criteria: 1. Parkinson's disease , spinocerebellar ataxia (SCA) and other secondary autonomic failure . 2. Vascular parkinsonism , Parkinsonism caused by stroke , tumor , or immune-mediated encephalitis .
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What it tests

  • We did not apply any interventions; only observational research was conducted.
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Where

20 sites
Changshu Hospital Affiliated to Nanjing University of Chinese Medicine
Changshu, China
The second People's Hospital of Huai'an
Huai'an, China
The First People's Hospial of Kunshan
Kunshan, China
Jiangsu Province Official Hospital
Nanjing, China
The Second Affiliated Hospital of Nantong University
Nantong, China
Jiangsu Province (Suqian) Hospital
Suqian, China
The Forth Affiliated Hospital of Soochow University
Suzhou, China
The Second Affiliated Hospital of Soochow University
Suzhou, China

…and 12 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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