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TwichView-guided Atricurium Dose Adjustment Trial

RecruitingNAAges 20 Years - anyAllFu Jen Catholic University Hospital
NCT07807046 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if using a monitor that measures muscle response can lower the amount of muscle relaxant medicine needed in adults who are treated in an intensive care unit (ICU) and need a continuous drip of a muscle relaxant called atracurium for more than 48 hours. The main questions it aims to answer are: Does using the monitor lower the infusion rate and total amount of atracurium given over 72 hours? Does using the monitor lower the complications related to atracurium use? Researchers will compare a group whose dose is guided by a muscle response monitor, aiming for a moderate level of muscle relaxation, to a group whose dose is guided by the usual bedside checks, to see if the monitor lowers the amount of medicine needed while keeping the same quality of care. Participants will: Receive atracurium as a continuous drip as part of their usual ICU trea

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult ICU patients (≥ 20 years of age) requiring continuous atracurium infusion for more than 48 hours due to any of the following conditions: * Moderate-to-severe ARDS (PaO₂/FiO₂ ratio ≤ 150) * Post-cardiac arrest care with device-controlled TTM (intravascular or surface cooling system) * Veno-venous (VV) or veno-arterial (VA) ECMO support Exclusion Criteria: * Patients aged under 20 years * Pregnant patients * Patients with known allergy to atracurium * Patients with a do-not-intervention order due to terminal disease * Patients with severe asthma, owing to the potential for atracurium-induced histamine release * Patients or their families who refuse to participate in the trial
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What it tests

  • EMG-based quantitative TOF-guided atracurium titration
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Where

1 site
Fu-Jen Catholic University Hospital
New Taipei City, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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