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Breast and Vascular Effects of Menopausal Hormone Therapy in Postmenopausal Women

Recruitingn/aAges 45 Years - 60 YearsFemaleSanliurfa Mehmet Akif Inan Education and Research…
NCT07810959 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective, single-center, observational controlled cohort study aims to evaluate the effects of menopausal hormone therapy (MHT) on breast imaging findings and carotid intima-media thickness in postmenopausal women. A total of 120 postmenopausal women will be enrolled. Participants will be observed in two groups according to their clinical management: women receiving systemic menopausal hormone therapy (n=70) and women not receiving systemic menopausal hormone therapy (n=50). Breast imaging findings, breast density, menopausal symptoms, endometrial findings, cardiometabolic parameters, and carotid intima-media thickness will be prospectively evaluated during a 12-month follow-up period.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women aged 45-60 years * Postmenopausal status, defined as at least 12 months of amenorrhea since the final menstrual period * Presentation with menopausal symptoms * Baseline breast ultrasonography available * Mammographic imaging performed within the previous 12 months * Ability to comply with the 12-month follow-up protocol * Provision of written informed consent Exclusion Criteria: * Perimenopausal status * Use of any menopausal hormone therapy within the previous 6 months * History of breast cancer or active breast cancer * Suspicious breast lesion at baseline imaging (BI-RADS category 4 or higher) * Unexplained uterine bleeding * Absolute contraindication to menopausal hormone therapy, including active thromboembolic disease, previous myocardial infarction, or active liver disease
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What it tests

  • Menopausal Hormone Therapy
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Where

1 site
Acıbadem Bursa Hospital
Bursa, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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