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Opioid-Free Anesthesia in FESS: A Prospective ERAS Study

Recruitingn/aAges 18 Years - 65 YearsAllFiliz Kaya
NCT07812389 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

1. Information for Patients and Families What is this study about? When patients undergo functional endoscopic sinus surgery (FESS), strong pain relievers called opioids are traditionally used during anesthesia. While effective, opioids can sometimes cause unwanted side effects such as nausea, vomiting, dizziness, or prolonged recovery times. This study investigates an "Opioid-Free Anesthesia" (OFA) approach combined with Enhanced Recovery After Surgery (ERAS) protocols. ERAS is a modern, science-based care pathway designed to help patients recover faster and more comfortably after surgery. Why is this study important? The goal of this study is to see if skipping opioids during sinus surgery-and using alternative pain-management techniques instead-leads to better perioperative outcomes. We want to find out if patients experience less pain, fewer side effects (like nausea), and a quic

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged between 18 and 65 years. * American Society of Anesthesiologists (ASA) physical status I or II. * Patients scheduled for elective Functional Endoscopic Sinus Surgery (FESS) due to chronic sinusitis. * Patients whose perioperative care is managed strictly according to institutional Enhanced Recovery After Surgery (ERAS) principles. * Both female and male patients are eligible for inclusion. Exclusion Criteria: * Known cardiac conduction abnormalities or arrhythmias. * History of chronic opioid use or opioid dependency. * Current use of beta-blockers or antiarrhythmic medications. * Severe hepatic or renal impairment. * Obesity defined as a Body Mass Index (BMI) greater than 35 kg/m². * Current use of GLP-1 receptor agonists. * Documented coagulopathy or bleeding disorders. * History of prior revision Functional Endoscopic Sinus Surgery (FESS) procedures. * History of delayed gastric emptying or high risk of pulmonary aspiration.
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What it tests

  • Dexmedetomidine
  • Remifentanil
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Where

1 site
Ankara Bilkent City Hospital
Ankara, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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