💬In plain words
What the trial is, and whether it could suit you
Cell therapies - including chimeric antigen receptor T-cell (CAR-T) therapy, tumor-infiltrating lymphocyte (TIL) therapy, T-cell receptor-engineered T-cell (TCR-T) therapy, and natural killer (NK) cell therapy - are emerging treatments for advanced solid tumors. However, their benefit-risk profiles remain uncertain: objective response rates in solid tumors are generally low, treatment-related toxicities such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) can be severe, and the manufacturing process is lengthy and costly. Little is known about how physicians and patients weigh these benefits, risks, and burdens when considering cell therapy for advanced solid tumors.
This cross-sectional, survey-based observational study will use a discrete choice experiment (DCE) to quantify and compare treatment preferences among approximately 420
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
* Physicians
Physicians must meet ALL of the following criteria:
1. Hold a valid medical practitioner license issued in the People's Republic of China and currently practice at a medical institution in China;
2. Specialize in medical oncology or another specialty directly involved in the diagnosis and treatment of solid tumors (e.g., thoracic oncology, gastrointestinal oncology, genitourinary oncology, or gynecologic oncology; surgical oncologists or radiation oncologists with prescribing authority for systemic anticancer therapy are also eligible);
3. Hold a professional title of attending physician or above;
4. Have directly participated in systemic treatment decision-making for patients with advanced (unresectable stage III or stage IV) solid tumors within the past 12 months;
5. Have a basic understanding of cell therapies (e.g., CAR-T, TIL, TCR-T, and NK cell therapies) and their therapeutic principles;
6. Participate voluntarily and provide electronic informed consent.
* Patients
Patients must meet ALL of the following criteria:
1. Aged 18 years or older;
2. Histologically or cytologically confirmed advanced solid tumor (unresectable stage III or stage IV; e.g., non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, gastric cancer, melanoma, or ovarian cancer);
3. Received at least one prior line of systemic anticancer therapy (chemotherapy, targeted therapy, immune checkpoint inhibitors, or other cellular immunotherapy) in the advanced or metastatic setting;
4. Eastern Cooperative Oncology Group (ECOG) performance status of 0-2, with adequate cognitive and physical capacity to complete the questionnaire;
5. Able to understand the questionnaire content independently or with assistance from a study coordinator;
6. Participate voluntarily and provide electronic informed consent.
Exclusion Criteria:
* Physicians
Physicians meeting ANY of the following criteria will be excluded:
1. Individuals engaged exclusively in basic research without direct involvement in clinical patient care;
2. Individuals unable, for any reason, to understand the questionnaire content or make independent judgments.
* Patients
Patients meeting ANY of the following criteria will be excluded:
1. Patients who are unaware of their tumor stage or treatment status;
2. Severe cognitive impairment or psychiatric disorders that preclude comprehension of the questionnaire content or independent judgment;
3. Estimated life expectancy of less than 3 months as assessed by the treating physician, or insufficient physical capacity to complete the questionnaire;
4. Uncontrolled acute illness or other urgent medical conditions that make study participation inadvisable.
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