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Human Sperm Cryopreservation as an Alternative to the Decline of Sperm Quality With Aging

Recruitingn/aAges 18 Years - 65 YearsMaleIVI Murcia
NCT07814235 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This observational study will evaluate whether sperm cryopreservation can help preserve sperm quality and molecular characteristics that may be affected by increasing paternal age. Men aged 18 years and older will provide a semen sample and a blood sample for laboratory analysis. Each semen sample will be divided into fresh, slow-frozen, and vitrified aliquots. The study will compare sperm quality (as assessed by computer-assisted sperm analysis), DNA methylation profiles, DNA fragmentation, sperm telomere length before and after cryopreservation. The effects of age on these parameters will also be assessed. The impact of age on seminal plasma extracellular vesicle composition and blood cell telomere length will also be analysed. The goal is to determine whether sperm cryopreservation may represent a strategy for preserving sperm characteristics associated with younger paternal age.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male participants aged 18 to 65 years * Attending IVI Murcia for semen analysis and/or assisted reproduction treatment * Able and willing to provide written informed consent * Willing to provide a semen sample and a blood sample for research purposes Exclusion Criteria: * Previous diagnosis of azoospermia or severe oligozoospermia (sperm concentration \<1 million sperm/mL) * Known chromosomal abnormality (abnormal karyotype) * Known Y chromosome microdeletion * Febrile illness within the previous 3 months * Presence of varicocele * Current use of vitamin or antioxidant supplements intended to improve semen quality
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What it tests

  • Not listed
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Where

1 site
IVI Murcia
Murcia, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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