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Clinical Efficacy and Safety of Left Bundle Branch Area Pacing Using Quantitative Guidance of Multimodal Data in the Treatment of Heart Failure

RecruitingNAAges 18 Years - 80 YearsAllSecond Affiliated Hospital of Nanchang University
NCT07814612 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Heart failure is a common chronic cardiovascular disease that seriously impairs patients' quality of life and long-term prognosis. When heart failure is complicated by complete left bundle branch block, the electrical signals that regulate orderly heart contraction cannot be transmitted normally along the left conduction pathway, causing the left and right ventricles to contract out of sync. This will gradually weaken the heart's pumping capacity, leading to symptoms such as exertional shortness of breath, persistent fatigue and body edema, and significantly increasing the risk of repeated hospital admissions and premature death. Traditional biventricular pacing is the standard treatment recommended by international clinical guidelines for this condition. By implanting pacing leads in both ventricles to deliver synchronized electrical stimulation, it restores cardiac synchrony, improves

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18-80 years; * Sinus rhythm, complete left bundle branch block (LBBB) fulfilling the Strauss criteria (QRS duration \>140 ms in men or \>130 ms in women); * Non-ischemic cardiomyopathy, left ventricular ejection fraction (LVEF) ≤40%, and New York Heart Association (NYHA) functional class II-IV; * Signed informed consent. * All enrolled patients received guideline-recommended pharmacological therapy for heart failure for at least 3 months. Exclusion Criteria: * Coronary CT-confirmed ischemic cardiomyopathy; * wide QRS complex with non-LBBB morphology, including right bundle branch block and nonspecific intraventricular conduction block; * persistent atrial fibrillation; * pacemaker replacement without reimplantation of ventricular leads; * patients with special conditions, such as pregnancy, gestation, and advanced malignancy. * All patients underwent detailed recording of electrophysiological pacing parameters intraoperatively and postoperatively, and monitoring for surgical complications.
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What it tests

  • Apply multimodal data fusion for quantitative guidance of left bundle branch region pacing
  • Conventional Biventricular Pacing
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Where

1 site
Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Nanchang, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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