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Comparison of FDG-PET/CT and CECT-CAP as Upfront Imaging Modality for the Diagnosis of Pyrexia of Unknown Origin

RecruitingNAAges 18 Years - anyAllPost Graduate Institute of Medical Education and …
NCT07816783 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Pyrexia of unknown origin (PUO) remains one of the most challenging diagnostic problems in modern medicine. Despite advances in laboratory diagnostics, microbiological techniques, imaging modalities, and molecular testing, a significant proportion of patients continue to undergo multiple, prolonged, expensive, and often invasive evaluations before a definitive diagnosis is established. PUO is classically defined as fever ≥38.3°C documented on ≥2 occasions AND duration ≥3 weeks or inpatient fever ≥1 week without diagnosis despite routine evaluation. The etiological spectrum of PUO is broad and heterogeneous. Causes are traditionally grouped into infections, malignancies, non-infectious inflammatory diseases, miscellaneous causes, and undiagnosed cases. Despite systematic evaluation, a definitive diagnosis is not achieved in a substantial proportion of patients, often ranging from 30-50%

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \> 18 years * irrespective of gender. * Fever ≥38.3°C documented on ≥2 occasions AND duration ≥3 weeks or inpatient fever ≥1 week without diagnosis despite routine evaluation. * Routine investigations to be done before labelling PUO: Full history \& examination, CBC, ESR/CRP, LFTs, RFTs, blood and urine cultures, urinalysis, ANA, RF, chest X-ray, abdominal ultrasound Exclusion Criteria: * Pregnancy. * Known case of immunosuppression * Contraindication or allergy to iodinated IV contrast (for CECT-CAP arm) that cannot be corrected * Prior FDG PET/CT or CECT-CAP performed prior to randomization for the current febrile illness that would preclude randomization
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What it tests

  • FDG-PET
  • CECT
  • Standard care of therapy
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Where

1 site
Post Graduate Institute of Medical Education and Research, Chandigarh, India
Chandigarh, India
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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