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Different Approaches for Alveolar Ridge Preservation

RecruitingNAAges 18 Years - anyAllDanae A. Apatzidou
NCT07818447 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Following tooth extraction, physiologic remodeling of the alveolar ridge results in significant horizontal and vertical bone resorption, often accompanied by soft tissue collapse. These dimensional changes may complicate future implant placement and compromise esthetic and functional outcomes. Alveolar ridge preservation techniques have been introduced to limit post-extraction tissue loss by supporting bone regeneration and stabilizing the soft tissues. A previously conducted study has shown optimal wound healing of a guided bone regeneration technique by employing a non-submerged barrier membrane versus a socket seal technique employing a free gingival graft versus unassisted healing. This prospective randomized controlled clinical trial aims to evaluate the effectiveness of alveolar ridge preservation using the combination of an allograft with either a platelet-rich fibrin (PRF) membr

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years. * Requirement for extraction of a single tooth affected by periodontal disease. * Presence of at least one adjacent tooth. * Loss of the buccal alveolar bone wall involving up to 50% of the socket wall. * Good general systemic health (American Society of Anesthesiologists ASA Physical Status I or II). * Satisfactory oral hygiene. * Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Systemic diseases or medications known to affect bone or soft tissue healing (e.g., uncontrolled diabetes mellitus, osteoporosis treated with bisphosphonates, or immunosuppressive therapy). * Heavy smoking (\>10 cigarettes/day). * Pregnancy or breastfeeding. * Presence of an acute infection or abscess at the extraction site. * History of radiotherapy to the head and neck region. * Inability or unwillingness to comply with the study protocol or attend scheduled follow-up visits.
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What it tests

  • Bone Allograft + Autologous Platelet-Rich Fibrin (PRF) Membrane
  • Control group
  • Bone Allograft + Resorbable Guided Bone Regeneration Membrane
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Where

1 site
Aristotle University of Thessaloniki, School of Dentistry, Faculty of Health Sciences, Postgraduate Periodontology Department
Thessaloniki, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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