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tACS for Self-Other Boundary in Schizophrenia

RecruitingNAAges 18 Years - 50 YearsAllChunyan Zhu
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In plain words

What the trial is, and whether it could suit you

This clinical trial investigates whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve the ability to distinguish between "self" and "others" in patients with schizophrenia. The intervention targets the medial prefrontal cortex (mPFC), a brain region critical for self-awareness, using 10Hz stimulation at 2mA for 20 minutes daily over five consecutive days. The study has two main objectives. First, it aims to characterize the underlying mechanisms of self-other boundary dysfunction in schizophrenia by comparing behavioral and brain activity patterns among three participant groups: patients with schizophrenia, individuals with high schizotypal traits, and healthy volunteers. During this mechanism phase, participants perform two computer-based self-other face recognition tasks designed to manipulate prior probability (vary

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of schizophrenia according to DSM-5 criteria * Presence of hallucinations or delusions * Age between 18 and 50 years * Clinically stable on a stable dose of antipsychotic medication for at least 4 weeks prior to enrollment, with no anticipated medication changes during the study period * Normal or corrected-to-normal vision (โ‰ฅ 20/40) as assessed by standard visual acuity test * Able to understand and provide written informed consent Exclusion Criteria: * History of neurological disorders (e.g., epilepsy, stroke, traumatic brain injury) * Presence of other major psychiatric disorders (e.g., bipolar disorder, major depressive disorder) * Previous receipt of non-invasive brain stimulation (e.g., tACS, tDCS, rTMS) * History of substance dependence or abuse within the past 6 months * Metal implants in the head or skull (e.g., cochlear implants, deep brain stimulators) * Pregnancy or breastfeeding * Presence of skin lesions, wounds, or sensitive skin at electrode placement sites (Fpz, AF7, AF8, F5, F6)
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What it tests

  • Transcranial Alternating Current Stimulation (tACS)
  • Sham Transcranial Alternating Current Stimulation (tACS)
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Where

1 site
The Fourth People's Hospital of Hefei
Hefei, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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