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7T Imaging Pilot-study in Patients With Motor Neuron Disease to Find Non-Invasive Disease Imaging Biomarkers

Recruitingn/aAges 18 Years - anyAllNHS Greater Glasgow and Clyde
NCT07818772 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Motor Neuron Disease (MND) is a neurodegenerative disorder, which causes progressive loss of nerve cells controlling the muscles responsible for movement, speech, swallowing and breathing. MND is not actually a single disease, but a range of diseases; some more serious with patients dying within a year, and some less severe cases with a life expectancy of several years. It is often difficult and can take a long time to get a diagnosis of MND, by which time patients are often already very unwell. The aim of this research study is to improve the diagnosis of MND and make it faster. The investigators plan to achieve this goal by using advanced Magnetic Resonance Imaging (MRI) to develop new diagnostic tests for MND. The investigators will use a scanner with a very strong magnetic field of 7 tesla (7T), which provides images of the brain with increased detail compared to standard MRI scanne

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male or non-pregnant female patients, ≥18 years of age * Able to give informed consent * Patients diagnosed as definite or probable motor neuron disease (El Escorial Criteria) Exclusion Criteria: * Contraindications to 7T MRI; * active implants, * tattoos in head and neck area * post-surgical brain implants and metal ware * Pregnancy * Unable to comfortably or safely lie flat in an MRI scanner * Respiratory failure * Known major other confounding neurological disease or previous brain surgery * Significant cognitive impairment, including loss of capacity secondary to fronto-temporal dementia * Unable to speak or understand any English (not complying with local 7T MRI safety SOPs) * Unlikely to be able to lie still for the duration of the scan.
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What it tests

  • MRI
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Where

1 site
ICE Building
Glasgow, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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