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Dexamethasone and Duration of Spinal Anesthesia

RecruitingPhase 4Ages 20 Years - 40 YearsAllHoly Family Hospital, Pakistan
NCT07819682 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will evaluate whether intravenous dexamethasone affects the duration of spinal anesthesia in patients undergoing lower abdominal surgery. Eligible adult patients classified as ASA I or II will undergo routine preoperative assessment by an anesthetist. Before surgery, patients will receive either intravenous dexamethasone (8 mg diluted in 100 mL normal saline) or 100 mL normal saline alone. The medication will be administered through a peripheral intravenous cannula. Spinal anesthesia will then be performed using a standard technique. A 25-gauge spinal needle will be used to administer 12-15 mg of 0.75% hyperbaric bupivacaine into the lower lumbar region while the patient is in the sitting position. After confirming the flow of cerebrospinal fluid, the patient will be positioned for surgery. The level and effectiveness of anesthesia will be assessed using standard sensory an

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients undergoing lower abdominal surgeries and orthopaedic surgeries including pelvic and lower extremity surgeries * Patients classified as American Society of Anesthesiologists (ASA) physical status I or II Exclusion Criteria: * Patients with a history of spinal surgery, spinal instrumentation, or previous failed spinal anaesthesia * Patients with pre-existing neurological disorders, peripheral neuropathy, or sensory/motor deficits * Patients with known hypersensitivity or allergy to local anaesthetic agents or dexamethasone * Patients with congenital spinal deformities or acquired spinal conditions such as advanced spondylosis or kyphoscoliosis that may interfere with neuraxial block * Patients with contraindications to spinal anaesthesia, including coagulopathy, local infection at the injection site, or raised intracranial pressure * Patients with diabetes mellitus, chronic steroid therapy, immunosuppression, or systemic infection (due to steroid use) * Pregnant patients or those undergoing emergency surgeries
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What it tests

  • Dexamethasone
  • Placebo
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Where

1 site
Holy Family Hospital
Rawalpindi, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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