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Inter-Limb Transfer in Acute Stroke

RecruitingNAAges 40 Years - 90 YearsAllUniversity Hospital of Mont-Godinne
NCT07822633 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to investigate whether the improvements achieved through motor skill learning (MSkL) with the ipsilesional upper limb (UL) are transferred to the contralesional UL during the (sub)acute stroke phase, and to identify the neural substrates underlying this inter-limb transfer. To achieve this, healthy individuals, acute and chronic stroke patients will perform proximal and distal MSkL tasks using serious games implemented on robotic devices. This will be complemented by behavioural assessments and multimodal MRI.

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📋 Eligibility rules (as published)
ACUTE STROKE PATIENTS: Inclusion Criteria: * First acute ischemic or hemorrhagic stroke * Between the 2nd and 21st day post-stroke * Age: 40-90 years * Ability to complete the 3 consecutive sessions Exclusion Criteria: * Stroke with multiple brain lesions * Addiction (e.g., alcohol or drugs) * Pregnancy * Major cognitive impairment (e.g., depression, aphasia, dementia) * Inability to perform or understand the required tasks * Uncontrolled health conditions * " classical " contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophobia, etc ...) HEALTHY INDIVIDUALS: Inclusion Criteria: * 40-90 years * availability to complete three consecutive sessions. Exclusion Criteria: * "classical" contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophobia, etc ...) * medical history with a previous stroke/relevant neurological deficit or disease * drug/alcohol abuse * psychiatric condition/dementia * having already used the robotic devices CHRONIC STROKE PATIENTS: Inclusion Criteria: * single stroke confirmed by brain imaging * time since stroke onset \>6 months * age between 40-90 years * availability to complete three consecutive sessions. Exclusion Criteria: * Stroke with multiple brain lesions * Addiction (e.g., alcohol or drugs) * Pregnancy * Major cognitive impairment (e.g., depression, aphasia, dementia) * Inability to perform or understand the required tasks * Uncontrolled health conditions * having already used the robotic devices
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What it tests

  • REAplan®
  • Dextrain Manipulandum®
  • REAplan®
  • Dextrain Manipulandum®
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Where

2 sites
CHU UCL Namur
Yvoir, Belgium
Cliniques universitaires Saint-Luc
Brussels, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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