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NAIF 2.0 - COGNIFY

Recruitingn/aAges 18 Years - 99 YearsAllHospital Universitari Vall d'Hebron Research Inst…
NCT07824297 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to learn whether intracranial dural arteriovenous fistulae, abnormal connections between arteries and veins in the covering of the brain, may affect a brain's waste-clearance system, known as the glymphatic system. The main question it aims to answer is: "Does glymphatic system function change after routine endovascular embolization of an intracranial dural arteriovenous fistula?" Participants who are already scheduled to receive endovascular embolization as part of their regular medical care will undergo advanced brain MRI before treatment and again about 6 months after treatment. Researchers will compare the MRI findings before and after embolization to explore whether treatment is associated with changes in glymphatic-related brain imaging markers.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged 18 to 99 years. * Angiographically confirmed diagnosis of unruptured intracranial dAVF. * Candidate for endovascular embolization treatment with curative intent. * Able to undergo Brain MRI. Exclusion Criteria: * Contraindication to angiographic embolization procedures. * Acute intracranial haemorrhage secondary to dAVFs rupture and/or venous hypertension. * Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study, other contraindications to MRI such as certain metallic implants.
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What it tests

  • Brain MRI
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Where

3 sites
Università di Bologna
Bologna, Italy
Hospital Universitario Vall D'Hebron
Barcelona, Spain
University of Oxford
Oxford, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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