"The Relationship Between Pulpal Inflammatory Marker Levels in Moderate and Severe Pulpitis and Outcome of Full Pulpotomy in Mandibular Molars With Extremely Deep Caries: A Prospective Cohort Study."

Inclusion Criteria: * o Medically healthy patients (ASA 1). * Age 18-40 years * Patients with extremely deep caries in permanent mandibular molars. * Extremely deep caries, that is penetrating the entire thickness of the dentine without a radiopaque zone separating the lesion from the pulp * PAI score less then or equal to 2 * Pulpal diagnosis via clinical and radiographic examination as well as thermal, electric pulp testing, categorized as moderate pulpitis (Heightened and prolonged reaction to cold, which can last for minutes Possible percussion sensitive Stimulated or spontaneous lingering pain that can be suppressed with analgesics. No sleep disturbance) or severe pulpitis (Severe spontaneous pain Clear lingering pain reaction to cold and warms stimuli Sleeping disturbance and lingering pain Possible sensitive to percussion Extremely deep caries mostly). Exclusion Criteria: * • Primary teeth * Traumatic or mechanical exposure * No pulp exposure after caries excavation. * Haemostasias not achieved within 10 minutes. * Presence of periapical lesion or evidence of internal or external resorption, calcified canals, as assessed by radiographic examination. * Patients with periodontal disease, swelling and sinus tract. * Immunocompromised or pregnant patients, patients with any systemic disease, and a positive history of antibiotic and analgesic use within week before the treatment.