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The Effect of Different rTMS Interventions on Acute Experimental Muscular Pain in Individuals Comorbid With Insomnia

RecruitingNAAges 18 Years - 60 YearsAllThe Hong Kong Polytechnic University
NCT07827677 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Insomnia exacerbates pain sensitivity and impairs physiological recovery from acute musculoskeletal pain. Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising non-invasive neuromodulation intervention to alleviate pain and modulate central sensory processing. However, whether rTMS can effectively mitigate insomnia-induced pain hyperalgesia and accelerate the recovery trajectory of acute musculoskeletal pain remains unclear, as does the optimal neuroanatomical stimulation target. Building upon an established experimental pain model, this randomized, sham-controlled study aims to evaluate the restorative effects of three distinct rTMS interventions - targeting the left primary motor cortex (L M1), the right dorsolateral prefrontal cortex (R DLPFC), and a sham condition - on individuals experiencing insomnia. Following a standardized eccentric exercise protocol to

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18 to 60 years * Right hand and foot dominant Exclusion Criteria: * History of any chronic musculoskeletal pain or presence of existing pain during recruitment * Previous major injuries or surgery involving the lower limbs * Sleep disorders other than insomnia * Clinically diagnosed psychiatric disorders * Conditions that preclude safe rTMS or pain testing (e.g., severe head trauma, intracranial hypertension, implanted ferromagnetic devices, history of epilepsy, skin conditions at stimulation sites) * Contraindications to vigorous exercise identified through the physical activity readiness questionnaire (PAR-Q) * Work night shifts or rotating shift schedules * Pregnant
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What it tests

  • Repetitive transcranial magnetic stimulation (rTMS) on L M1
  • Repetitive transcranial magnetic stimulation (rTMS) on R DLPFC
  • Sham repetitive transcranial magnetic stimulation (rTMS)
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Where

1 site
The Hong Kong Polytechnic University
Hong Kong, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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