💬In plain words
What the trial is, and whether it could suit you
This study aims to investigate the role of skeletal muscle mitochondrial dysfunction in the development of frailty in older adults and to evaluate whether a short-term, supervised resistance training intervention can improve skeletal muscle health and physical function.
Frailty is a common age-related condition associated with increased vulnerability to disability, hospitalisation, and loss of independence. It is characterised by features that may include weakness, fatigue, reduced physical activity, and slower walking speed. Mitochondrial dysfunction in skeletal muscle may contribute to the development of frailty and may be further influenced by chronic conditions such as type 2 diabetes mellitus (T2DM), which are associated with metabolic alterations, inflammation, oxidative stress, and insulin resistance.
Resistance training is an effective strategy to counteract age-related decline
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
* Inclusion criteria for young controls
* Healthy young adults (18-35 years old)
* Without any pathology or treatment
* Inclusion criteria for older controls
* Healthy older adults (65 years or older)
* Not currently enrolled in a resistance training program
* Inclusion criteria for cases
* Age over 65 years
* Diagnosis of frailty or robustness
* Diagnosis of type 2 diabetes mellitus
* Glycosylated hemoglobin (HbA1c) less than 9%
* Treatment with metformin
* Not currently enrolled in a resistance training program
Exclusion Criteria:
* Exclusion criteria for young controls
* Pregnancy or suspected pregnancy
* Body mass index greater than 35 kg/m2
* Treatment within the last 30 days with oral corticosteroids
* Edema or severe fluid regulation disorders that could alter bioimpedance results
* Allergy to the local anesthetic mepivacaine
* Prostheses, metal implants, or surgical staples lodinated or barium contrast for other imaging tests within the last 7 days
* Exclusion criteria for older controls
* Decompensated and uncontrolled chronic diagnoses
* Body mass index greater than 35 kg/m2
* Treatment within the last 30 days with oral corticosteroids
* Systemic diseases, active oncological disease, liver cirrhosis, untreated hypothyroidism, or severe chronic obstructive pulmonary disease (COPD).
* Severe edema or fluid regulation disorders that could alter bioimpedance results
* Allergy to the local anesthetic mepivacaine
* Prostheses, metal implants, or surgical staples Iodinated or barium contrast for other imaging tests in the last 7 days
* Exclusion criteria for cases
* Diagnosis of pre-frailty
* Age over 80 years
* Body mass index greater than 35 kg/m2
* Time since onset of diabetes mellitus type 2 less than 10 years
* Treatment with insulin
* Treatment with allopurinol
* Treatment with anticoagulant or antiplatelet drugs
* Treatment within the last 30 days with oral corticosteroids
* Advanced chronic complications of diabetes mellitus type 2 :
Renal failure (clearance \<30 ml/min/m2) Macroalbuminuria greater than 200 mg/g Ischemic vascular diseases (acute myocardial infarction) Myocardial infarction, angina, stroke) Proliferative retinopathy or laser therapy Ulcerated diabetic foot or lower limb amputations, except for digital amputations
* Systemic diseases, active oncological disease, liver cirrhosis, untreated hypothyroidism, or severe chronic obstructive pulmonary disease
* Physical limitations in the lower limbs (acute or acute-on-chronic inflammatory processes, limited joint range of motion, chronic pain (visual analogue scale for pain \> or = 4, etc.)
* Senile dementia
* Edema or severe fluid regulation disorders that may alter bioimpedance results
* Allergy to the local anesthetic mepivacaine
* Pacemaker, metallic prostheses or implants, surgical staples, and radiopaque tubes or catheters Iodinated or barium contrast for other imaging tests within the last 7 days
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