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FueL Use During eXercise in Males and Females

RecruitingNAAges 18 Years - 35 YearsAllUniversity of Toronto
NCT07829237 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study will investigate whether pre-exercise nutrition influences sex differences in fuel utilization during endurance exercise. Twenty-four recreationally active adults (12 females and 12 males) will complete three experimental exercise trials in a randomized, counterbalanced crossover design. Before each trial, participants will consume either a carbohydrate beverage, a protein-based beverage, or a flavour-matched non-caloric beverage representing the fasted condition. Thirty minutes later, participants will complete 90 minutes of moderate-intensity cycling followed by a cycling time-to-task-failure test. Whole-body carbohydrate and fat oxidation, exogenous substrate oxidation, blood metabolites, and exercise performance will be assessed.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participating in ≥150 minutes of moderate-to-vigorous physical activity per week * VO₂peak classified as "good" or above based on American College of Sports Medicine normative values: \>35.0 mL/kg/min for females and \>39.0 mL/kg/min for males * Body mass index (BMI) between 18 and 27 kg/m² * Participating in 3-5 structured exercise sessions per week * Weight stable, defined as within ±2 kg for at least 6 months * Non-smoker * Females must be eumenorrheic Exclusion Criteria: * Polycystic ovarian syndrome (PCOS) or endometriosis Current use of oral contraceptives or oral contraceptive use within the previous 3 months Diagnosed cardiovascular or metabolic disease Hypergonadism or hypogonadism Use of medications for management of blood glucose or lipid metabolism Pregnant or \<12 months postpartum Lactating or breastfeeding within 3 months of study commencement Menopausal Recreational tobacco smoking Inability to complete the study exercise protocols or comply with pre-trial dietary or physical activity controls Use of medications that may affect substrate metabolism, including corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs) Currently following a low-carbohydrate diet, such as a ketogenic or Atkins diet
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What it tests

  • Pre-exercise carbohydrate beverage
  • Pre-exercise protein beverage
  • Fasted control beverage
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Where

1 site
Goldring Centre for High Performance Sport
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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