🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Facial Skin Microbiome in Patients With Moderate-to-Severe Acne Vulgaris Treated With Isotretinoin

Recruitingn/aAges 16 Years - 35 YearsAllCan Tho University of Medicine and Pharmacy
NCT07834138 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Acne vulgaris is associated with changes in the facial skin microbiome, but longitudinal microbiome changes during isotretinoin therapy remain incompletely understood. This prospective observational cohort study aims to characterize the facial skin microbiome in patients with moderate-to-severe acne vulgaris before and during isotretinoin treatment and to compare microbiome profiles with healthy individuals. Participants with moderate-to-severe acne vulgaris receiving standard-of-care oral isotretinoin will be followed prospectively. Facial skin swab samples will be collected before treatment and at scheduled follow-up visits during therapy. Healthy volunteers without acne will provide a single facial skin swab for comparison. Bacterial communities will be analyzed using 16S rRNA gene sequencing, and clinical severity will be assessed using validated acne severity scores and lesion coun

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: Acne Vulgaris Cohort: * Participants aged 16-35 years. * Clinical diagnosis of acne vulgaris. * Presence of acne lesions on both cheeks. * Indication for oral isotretinoin treatment according to clinical assessment at Can Tho University of Medicine and Pharmacy Hospital. * Willingness to participate in the study. Healthy Control Cohort: * Voluntary participation in the study. * No history or clinical manifestations of acne vulgaris. * No use of antibiotics or isotretinoin within the previous 6 months. * No lesions of other skin diseases on the face. Exclusion Criteria: * Current dermatologic diseases such as rosacea, contact dermatitis, eczema, or psoriasis. * Current acute or chronic medical diseases. * Use of antibiotics or isotretinoin within the previous 3 months. * Use of phototherapy or topical probiotics on the facial skin within the previous 3 months. * Use of facial cleansing products or topical medications within 24 hours before sample collection. * History of allergy. * Unwillingness to participate in the study.
💊

What it tests

  • ISOtretinoin 10 MG
📍

Where

1 site
Can Tho University of Medicine and Pharmacy Hospital
Can Tho, Vietnam
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy