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Treating Intrabony Defect With MINST VS MINST Extended PRF

RecruitingNAAges 18 Years - anyAllCairo University
NCT07836231 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study evaluates a minimally invasive non-surgical technique (MINST) for treating periodontal intrabony defects, with or without the addition of Extended Platelet-Rich Fibrin (e-PRF). The goal is to determine which approach provides better bone regeneration and gum healing. Study Procedures Control Group: Local anesthesia by infiltration at the treatment site Instrumentation of the root surface up to the bottom of the periodontal pocket Efforts are made to minimize trauma to soft tissues and interdental papilla using subpapillary access Cleaning is performed using piezo-electric devices with delicate tips, avoiding aggressive root smoothing or gingival curettage 3-4× magnification loupes are used to improve precision Intervention Group: All the above procedures Followed by injection of e-PRF, a preparation derived from the patient's own blood Blood is collected in 4 mL tub

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📋 Eligibility rules (as published)
Inclusion Criteria: Adults aged above 21 years. Clinical diagnosis of Stage III periodontitis. Presence of at least two isolated interproximal intrabony defects located in different quadrants. Intrabony defect associated with a single-rooted tooth or mandibular molar without furcation involvement. Probing depth (PD) ≥ 6 mm. Radiographic intrabony defect depth between 3 and 7 mm. Absence of periapical pathology at the study site. Absence of acute periodontal infection. Absence of subgingival restorations that could interfere with clinical measurements. Absence of Grade II or Grade III tooth mobility. Ability and willingness to provide written informed consent. Exclusion Criteria: Pregnancy or lactation. Non-surgical periodontal therapy within the previous 6 months. Surgical periodontal therapy within the previous 12 months. History of radiotherapy to the head and neck region. Current smoking. Eligibility note: Former smokers and never-smokers are eligible.
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What it tests

  • Extended Platelet-Rich Fibrin (e-PRF)
  • Modified Minimally Invasive Non-Surgical Technique (MINST)
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Where

1 site
Faculty of Dentistry, Cairo University
Giza, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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