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โ† Trials
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Effect of Messaging on Pragmatic Outcomes Within an Integrated Healthcare System

RecruitingNAAges 18 Years - anyAllKaiser Permanente
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In plain words

What the trial is, and whether it could suit you

COVID-19 vaccination among patients at high risk for severe disease has declined in the United States since 2022. Prior research, including discrete choice experiments (DCEs), has demonstrated that vaccine preferences are influenced by attributes such as effectiveness, safety, convenience, and protection against severe disease. Although DCEs provide valuable insights into stated vaccine preferences and decision-making, they rely on hypothetical scenarios and cannot directly assess how vaccine attributes influence real-world vaccine uptake. Additional research is needed to understand the relationship between vaccine characteristics and observed COVID-19 vaccination behavior in routine clinical practice. The EMPOWeR study is a pragmatic randomized controlled trial conducted within Kaiser Permanente Southern California (KPSC) to evaluate the effect of immunization messages and reminders th

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Aged โ‰ฅ18 years; * Active KPSC member; * Continuous membership from 27 August 2025 to 28 September 2026; * Members who are aged 65 years and older, or adults aged 18-64 years with at least one of the following health conditions that increases their risk for severe COVID-19 illness, including: a) asthma, b) cancer, c) ischemic stroke, d) intracerebral or subarachnoid hemorrhage, e) transient ischemic attack, f) chronic kidney disease, g) dialysis, h) bronchiectasis, i) chronic obstructive, pulmonary disease (COPD), j) pulmonary fibrosis, k) cystic fibrosis, l) pulmonary hypertension, m) cirrhosis, n) non-alcoholic fatty liver disease (NALD), o) alcoholic liver disease, p) autoimmune hepatitis, q) diabetes, r) heart failure, s) coronary artery disease, t) cardiomyopathy, u) HIV, v) obesity, w) essential hypertension, x) primary immunodeficiency and other underlying immunocompromising conditions, y) solid organ or blood stem cell transplant, z) tuberculosis; * No documented receipt of updated 2026-27 COVID-19 vaccine as of 28 September 2026; * Has valid email information. Exclusion Criteria: * Unable to receive or opted out of email communication. * People with unknown or missing sex. * People who cannot safely receive a COVID-19 vaccine, including those who had a severe allergic reaction to a previous COVID-19 vaccine or have a contraindication to COVID-19 vaccine or a vaccine ingredient, will not be included in the study. * People with metastatic or terminal illness, advanced illness, receiving hospice or palliative care, or resident in skilled nursing facilities. * People who are pregnant or currently breastfeeding.
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What it tests

  • Vaccine choice message
  • Vaccine choice + platform-framed message
  • Vaccine choice + HCP trust-framed message
  • Vaccine choice + reactogenicity-framed message
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Where

1 site
Kaiser Permanente Southern California, Department of Research & Evaluation
Pasadena, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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