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Oromucosal Oxytocin and Vasopressin Modulation of Emotional Face Attention

RecruitingNAAges 18 Years - 30 YearsAllUniversity of Electronic Science and Technology o…
NCT07838493 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn how 24 IU oxytocin (OT) and 24 IU arginine vasopressin (AVP), administered through the oral mucosa, affect attention to emotional faces and related brain activity in healthy adults. The study will compare OT and AVP with a placebo (PLC). The main questions it aims to answer are: 1. Does oromucosally administered oxytocin produce a behavioral pattern of modulation of top-down and bottom-up attention to emotional faces that is qualitatively consistent with previously reported intranasal oxytocin effects, and how does this pattern compare with that produced by arginine vasopressin? 2. Do oromucosally administered oxytocin and arginine vasopressin modulate neural responses within predefined brain regions and networks involved in emotional salience, attentional control, and social information processing, and are these neural effects consistent wit

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy subjects without past or current psychiatric or neurological disorders * Normal or corrected-to-normal vision * Eligible for MRI scanning and willing to undergo blood sampling and study treatment administration * For naturally cycling female participants, willingness and ability to complete the experimental session within the predefined menstrual-cycle phase, determined using menstrual history and urinary luteinizing hormone (LH) testing * Willing to comply with study requirements regarding alcohol, caffeine, nicotine, medication use, and other pre-session restrictions Exclusion Criteria: * History of head injury or epilepsy or seizure disorders * Current or past major psychiatric, neurological, or serious medical illness that may affect participant safety or study outcomes * Current use of psychoactive medications, hormonal medications, or other medications that may substantially affect central nervous system or neuroendocrine function * Regular smoking or inability to comply with the required nicotine abstinence period before testing * Face recognition impairment or other visual-perceptual impairment that could interfere with performance of the emotional face tasks
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What it tests

  • Oxytocin (OT)
  • Arginine Vasopressin (AVP)
  • Placebo (PLC)
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Where

1 site
University of Electronic Science and Technology of China
Chengdu, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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