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Multimodal Prehabilitation in Gastric Cancer Patients

RecruitingNAAges 22 Years - 99 YearsAllNational University Hospital, Singapore
NCT07839702 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This single-arm phase II trial investigates whether a multimodal prehabilitation program can attenuate the postoperative inflammatory response in patients undergoing curative gastric cancer surgery. Major abdominal surgery induces a pronounced systemic inflammatory reaction that contributes to postoperative complications, delayed recovery, impaired functional status, and reduced tolerance to adjuvant therapy. Elevated postoperative C-reactive protein (CRP) trajectories have been associated with infectious complications, whereas a timely decline in CRP may reflect a more adequate immune response. Interventions that improve nutritional status, physical fitness, and psychological resilience before surgery may modulate these inflammatory processes. The PING-P intervention combines three components starting two weeks before surgery and continuing for three weeks postoperatively: (1) structur

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Adult patients (22 to 99 years). 2. Histologically confirmed gastric or esophagogastric junction cancer (Siewert type II/III). 3. Scheduled for curative surgery (laparoscopic or robotic subtotal, total, or proximal gastrectomy). 4. No distant metastasis (M0). 5. Tolerating oral intake. 6. Limited esophageal involvement (≤2 cm), no duodenal invasion. 6.7. Patients with musculoskeletal limitations (exercises will be adopted accordingly) 7.8. Informed consent provided and capable of complying with home-based program. 8.9. No indication for total parenteral or tube feeding. 9.10. ECOG status compatible with intervention. 10.11. ASA class I-III. Exclusion Criteria: 1. Cognitive impairment, dementia, or psychiatric illness preventing consent or compliance. 2. Emergency surgery or intraoperative conversion to open surgery. 3. Need for preoperative enteral or parenteral feeding. 4. Severe comorbidities requiring multiple organ resection (except cholecystectomy). 5. Allergy or intolerance to components of the ONS product. 6. Severe mMotor impairments affecting ability to perform exercises or complete outcome assessments. 7. Patients under palliative care or rejecting curative treatment. 8. Pregnant and lactating females 9. Existing active electronic implants (e.g., pacemaker, defibrillator) or electromechanical medical device (e.g. insulin pump) 10. Inflamed areas or skin eruptions on the legs
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What it tests

  • prehabilitation
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Where

1 site
National University Hospital
Singapore, Singapore
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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