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Dynamic Non-invasive Monitoring of Inspiratory Effort

Recruitingn/aAges any - anyAllFundació d'investigació Sanitària de les Illes Ba…
NCT07839949 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective, observational cohort study aims to evaluate whether the dynamic monitoring of a patient's breathing effort can predict successful liberation from invasive mechanical ventilation. The study will include 120 patients who have undergone 36 hours or more of controlled mechanical ventilation and deep sedation. Patient monitoring will commence immediately upon their transition to an assisted spontaneous breathing mode with pressure support. Starting from this clinical milestone, the researchers will track the patients' longitudinal inspiratory effort daily through four specific variables: maximum occlusion pressure, muscle pressure index, flow index via visual waveform inspection, and diaphragmatic thickening fraction via ultrasound. Concurrently, ventilator safety parameters (plateau pressure, driving pressure, transpulmonary pressure, and compliance) will be recorded. The p

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years old or more. * Patients undergoing invasive mechanical ventilation for any cause under a controlled ventilation mode for more than 36 hours. * Attending physician's decision to initiate pressure support ventilation according to standard clinical practice. Exclusion Criteria: * Pregnancy. * Degenerative neuromuscular disease (e.g., amyotrophic lateral sclerosis, congenital myopathies). * Air leak/fistula that prevents breathing-pause maneuvers. * Diaphragmatic paralysis. * Limitation of life-sustaining treatment in case of weaning failure. * Conditions preventing follow-up up to 72 hours after liberation from mechanical ventilation. * Use of neuromuscular blocking agents within the last 24 hours.
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What it tests

  • Not listed
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Where

1 site
Department of Intensive Care Medicine, Hospital Universitario Son Espases
Palma de Mallorca, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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