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โ† Trials
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Transoral Nasal Cannula Oxygen Therapy for Mouth-Breathing Patients in the Postanesthesia Care Unit

RecruitingNAAges 18 Years - anyAllNanjing First Hospital, Nanjing Medical University
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In plain words

What the trial is, and whether it could suit you

Postoperative hypoxemia is a common complication in the postanesthesia care unit (PACU). Patients who breathe through the mouth after tracheal extubation may receive limited benefit from standard nasal cannula oxygen therapy, because the nasal cavity functions as an ineffective dead space during mouth breathing. Clinical observations suggest that placing the prongs of a nasal cannula inside the mouth (transoral oxygen delivery) rapidly improves oxygenation in these patients. However, no randomized controlled trial has formally verified this effect. This single-center, randomized, controlled, crossover trial will enroll 64 adult patients identified as persistent mouth breathers after extubation in the PACU following elective thoracic or abdominal surgery under general anesthesia. Each participant will receive, in a randomized sequence, both standard nasal cannula oxygen delivery (4 L/min

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Aged older than 18 years; 2. American Society of Anesthesiologists (ASA) physical status classification I-III; 3. Undergoing elective thoracic or abdominal surgery under general anesthesia with postoperative transfer to the postanesthesia care unit (PACU); 4. Anticipated PACU stay of at least 30 minutes to allow an adequate observation window for data collection; 5. Recovery of spontaneous breathing after tracheal extubation, and confirmed as persistent mouth breathing by the standardized three-step assessment procedure (visual screening, cotton-fiber airflow verification, and mirror confirmation); 6. Written informed consent signed by the patient or a family member. Exclusion Criteria: 1. Preoperative diagnosis of severe obstructive sleep apnea-hypopnea syndrome (apnea-hypopnea index \[AHI\] \>30) or requirement for continuous positive airway pressure therapy; 2. Severe hypoxemia requiring immediate escalation of oxygen therapy (SpO2 \<90% or PaO2 \<60 mmHg); 3. Requirement for reintubation or placement of an oropharyngeal or nasopharyngeal airway after surgery; 4. Hemodynamic instability requiring vasoactive agents to maintain mean arterial pressure (MAP \<65 mmHg).
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What it tests

  • Transoral nasal cannula oxygen delivery
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Where

1 site
Nanjing First Hospital, Nanjing Medical University
Nanjing, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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