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โ† Trials
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Optimising Antibiotic Use for Paediatric Lower Respiratory Tract Infections in Africa

RecruitingNAAges 2 Months - 24 MonthsAllUniversity of Witwatersrand, South Africa
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In plain words

What the trial is, and whether it could suit you

Lower respiratory tract infections (LRTIs) remain a leading cause of hospitalisation and death among young children in Africa. Although viral infections account for a substantial proportion of LRTIs, antibiotics are frequently prescribed because distinguishing between viral and bacterial infections can be challenging. This contributes to unnecessary antibiotic exposure and the rising global public health challenge of antimicrobial resistance. This pragmatic, unblinded randomised controlled study will evaluate whether the combination of point-of-care (POC) C-reactive protein (CRP) testing and the PREPARE clinical severity score can safely reduce antibiotic use among children aged 2 to 24 months hospitalised with LRTI at Chris Hani Baragwanath Academic Hospital (CHBAH), South Africa. Participants will be randomly assigned in a 1:1 ratio to either the intervention group, where antibiotic d

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Children between the ages of 2-24 months * Clinician diagnosis of lower respiratory tract infection (LRTI) Exclusion Criteria: * Transferred from other hospitals with more than 24 hours of hospitalisation * Hospitalisation within the preceding 30 days
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What it tests

  • CRP- and PREPARE-guided Antibiotic Prescription
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Where

1 site
Chris Hani Baragwanath Academic Hospital
Johannesburg, South Africa
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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