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Perioperative GFAP and Neurological Complications After Carotid Endarterectomy

Recruitingn/aAges 35 Years - 90 YearsAllFiliz Ata
NCT07843979 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective, single-center observational study will evaluate whether blood levels of glial fibrillary acidic protein (GFAP), a protein associated with injury to supporting cells in the brain, are related to neurological complications after carotid endarterectomy. Adults aged 35 to 90 years undergoing elective isolated carotid endarterectomy will be enrolled. Serum GFAP will be measured before surgery and 24 hours after surgery. Investigators will record perioperative clinical information and postoperative neurological outcomes, including transient ischemic attack, stroke, delirium, and cognitive dysfunction. Approximately 90 participants are planned. The study will not assign any treatment or procedure.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 35 to 90 years * Scheduled to undergo elective isolated carotid endarterectomy * Willing and able to provide informed consent and the required blood samples Exclusion Criteria: * Acute coronary syndrome within the previous 3 months * Carotid endarterectomy planned in combination with another surgical procedure * Atrial fibrillation * Known inflammatory disease * Hematologic disease * Refusal to provide preoperative consent or a blood sample * Stroke with residual neurological sequelae within the previous year * Multiple sclerosis, Alzheimer disease, Parkinson disease, or another pre-existing neurological disease
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What it tests

  • Serum GFAP Measurement
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Where

1 site
University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital
Bursa, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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